{slider Infection by zika virus increase angiotensin I-converting enzyme activity in mouse brain}

Oyadomari WY, Christoff RR, Nani JV, Rabello T, Oliveira V, Higa LM, Garcez PP, Hayashi MAF. Infection by zika virus increase angiotensin I-converting enzyme activity in mouse brain. Biochimie. 2024 Jul 2:S0300-9084(24)00160-3. doi: 10.1016/j.biochi.2024.07.001.

{slider Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms}

Courchesne E, Taluja V, Nazari S, Aamodt CM, Pierce K, Duan K, Stophaeros S, Lopez L, Barnes CC, Troxel J, Campbell K, Wang T, Hoekzema K, Eichler EE, Nani JV, Pontes W, Sanchez SS, Lombardo MV, de Souza JS, Hayashi MAF, Muotri AR. Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms. Mol Autism. 2024 May 25;15(1):22. doi: 10.1186/s13229-024-00602-8.

{slider Sodium nitroprusside as an adjunctive treatment for schizophrenia reduces the Ndel1 oligopeptidase activity}

Nani JV, Ushirohira JM, Bradshaw NJ, Machado-de-Sousa JP, Hallak JEC, Hayashi MAF. Sodium nitroprusside as an adjunctive treatment for schizophrenia reduces the Ndel1 oligopeptidase activity. Braz J Psychiatry. 2023 Nov 23. doi: 10.47626/1516-4446-2023-3315. doi: 10.47626/1516-4446-2023-3315. Online ahead of print.

{slider Identification of an ex vivo inhibitor of the schizophrenia biomarker Ndel1 by high throughput screening}

Nani JV, Coelho C, Oyadomari WY, Santiago TC, Machado MM, Christoff RR, Garcez PP, Oliveira V, Würtele M, Hayashi MAF. EIdentification of an ex vivo inhibitor of the schizophrenia biomarker Ndel1 by high throughput screening. Biochem Pharmacol. 2023 Oct 9;217:115841. https://doi.org/10.1016/j.bcp.2023.115841

{slider Evaluation of tumor growth remission in a murine model for subcutaneous solid tumors – Benefits of associating the antitumor agent crotamine with mesoporous nanosilica particles to achieve improved dosing frequency and efficacy.}

Oyadomari WY, Anthero GL, Silva MRA, Porta LC, Oliveira V, Reid PF, Sant'Anna OA, Alves WA, Nani JV, Hayashi MAF. Evaluation of tumor growth remission in a murine model for subcutaneous solid tumors – Benefits of associating the antitumor agent crotamine with mesoporous nanosilica particles to achieve improved dosing frequency and efficacy. Int. J. Pharm. 2023 646(5), 123420. https://doi.org/10.1016/j.ijpharm.2023.123420

{slider Euthymic and depressed bipolar patients are characterized by different RNA editing patterns in blood}

Hayashi MAF, Salvetat N, Cayzac C, Checa-Robles FJ, Dubuc B, Mereuze S, Nani JV, Molina F, Brietske E, Weissmann D. Euthymic and depressed bipolar patients are characterized by different RNA editing patterns in blood. Psychiatry Res. 2023 Aug 18. https://doi.org/10.1016/j.psychres.2023.115422.

{slider Assessing the role of Ndel1 oligopeptidase activity in congenital Zika syndrome: Potential predictor of congenital syndrome endophenotype and treatment response}

Christoff RR, Nani JV, Lessa G, Rabello T, Rossi AD, Krenn V, Higa LM, Tanuri A, Garcez PP, Hayashi MAF. Assessing the role of Ndel1 oligopeptidase activity in congenital Zika syndrome: Potential predictor of congenital syndrome endophenotype and treatment response. J Neurochem. 2023 Jul 27. doi: 10.1111/jnc.15918.

{slider [18F]F-FDG and [11C]PK11195 PET imaging in the evaluation of brown adipose tissue - effects of cold and pharmacological stimuli and their association with crotamine intake in a male mouse model}

Daniele de Paula Faria, Joana D'Arc Campeiro, Mara de Souza Junqueira, Caroline Cristiano Real, Fabio Luiz Navarro Marques, Mirian Akemi Furuie Hayashi, Marcelo Tatit Sapienza. [18F]F-FDG and [11C]PK11195 PET imaging in the evaluation of brown adipose tissue - effects of cold and pharmacological stimuli and their association with crotamine intake in a male mouse model. Nucl Med Biol. 2023 Jun 17;122-123:108362. doi: 10.1016/j.nucmedbio.2023.108362

{slider Crotamine/siRNA Nanocomplexes for Functional Downregulation of Syndecan-1 in Renal Proximal Tubular Epithelial Cells}

Joana D’Arc Campeiro, Wendy A. Dam, Mirian A. F. Hayashi, and Jacob van den Born. Crotamine/siRNA Nanocomplexes for Functional Downregulation of Syndecan-1 in Renal Proximal Tubular Epithelial Cells. Pharmaceutics 2023, 15, 1576. https://doi.org/10.3390/pharmaceutics15061576.

{slider Prolyl oligopeptidase activity (POP) in early stage and medicated schizophrenia and in an animal model for schizophrenia study: in vivo effects of psychopharmacological substances on enzyme activity}

Lucas A.N. Marins, Benjamín Rodríguez, João V. Nania, Vitor Oliveira Ary Gadelha, Mirian A.F. Hayashi. Prolyl oligopeptidase activity (POP) in early stage and medicated schizophrenia and in an animal model for schizophrenia study: in vivo effects of psychopharmacological substances on enzyme activity. Brain Disorders 10 (2023) 100075. doi: 10.1016/j.dscb.2023.100075.

{slider Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease}

Boeynaems S, Ma XR, Yeong V, Ginell GM, Chen JH, Blum JA, Nakayama L, Sanyal A, Briner A, Van Haver D, Pauwels J, Ekman A, Schmidt HB, Sundararajan K, Porta L, Lasker K, Larabell C, Hayashi MAF, Kundaje A, Impens F, Obermeyer A, Holehouse AS, Gitler AD.Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease. bioRxiv. 2023 Mar 9:2023.03.09.531820. doi: 10.1101/2023.03.09.531820.

{slider Angiotensin Converting Enzymes as druggable features of psychiatric and neurodegenerative disorders}

Santiago TC, Parra L, Nani JV, Fidalgo TM, Bradshaw NJ, Hayashi MAF.. Angiotensin Converting Enzymes as druggable features of psychiatric and neurodegenerative disorders. J Neurochem. 2023 Mar 12.doi: 10.1111/jnc.15806.

{slider ¹H NMR Metabolomics and Lipidomics To Monitor Positive Responses in Children with Autism Spectrum Disorder Following a Guided Parental Intervention: A Pilot Study}

Banny Silva Barbosa Correia, João Guilherme de Moraes Pontes, João Victor Silva Nani, Fabian Villalta, Natalia Cristina Mor, Daniela Bordini, Décio Brunoni, Helena Brentani, Jair Jesus Mari, Mirian A. F. Hayashi*, and Ljubica Tasic*. 1H NMR Metabolomics and Lipidomics To Monitor Positive Responses in Children with Autism Spectrum Disorder Following a Guided Parental Intervention: A Pilot Study. ACS Chem Neurosci. 2023 Mar 15;14(6):1137-1145. doi: 10.1021/acschemneuro.2c00735.

{slider Doderlin: Isolation and Characterization of a Broad-Spectrum Antimicrobial Peptide from Lactobacillus acidophilus}

Bruna S.da Silva, AndreaDíaz-Roa, Erica S.Yamane, Mirian A.F.Hayashi, Pedro Ismael da Silva Junior. Doderlin: Isolation and Characterization of a Broad-Spectrum Antimicrobial Peptide from Lactobacillus acidophilus. Research in Microbiology 174 (2023) 103995. https://doi.org/10.1016/j.resmic.2022.103995.

{slider Targeting Ca²⁺ and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells}

Vivian W. R. Moraes, Vivian Matsukura dos Santos, Eloah R. Suarez, Leticia S. Ferraz, Rayssa M. Lopes, Giuliana P. Mognol, Joana D. Campeiro, João Agostinho Machado-Neto, Fabio D. Nascimento, Mirian A.F. Hayashi, Ivarne L.S. Tersariol, Donald D. Newmeyer, Tiago Rodrigues. Targeting Ca²⁺ and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells. Life 2022;12:1477. https://doi.org/10.3390/life12101477.

 {slider Brief reports unraveling the correlation among neurodevelopmental and inflammatory biomarkers in patients with chronic schizophrenia}

Nani JV, Almeida PGC, Noto C, Bressan RA, Brietzke E, Hayashi MAF. BRIEF REPORTS UNRAVEILING THE CORRELATION AMONG NEURODEVELOPMENTAL AND INFLAMMATORY BIOMARKERS IN PATIENTS WITH CHRONIC SCHIZOPHRENIA. Nord J Psychiatry. 2022 Oct;76(7):559-564. doi: 10.1080/08039488.2021.2023217.

{slider Crotamine trafficking dynamic in Plasmodium falciparum-infected erythrocytes: pharmacological inhibitors, parasite cycle and incubation time influences in uptake}

El Chamy Maluf S, Hayashi MAF, Campeiro JD, Oliveira EB, Gazarini ML, Carmona AK. Crotamine trafficking dynamic in Plasmodium falciparum-infected erythrocytes: pharmacological inhibitors, parasite cycle and incubation time influences in uptake. Toxicon. 202;208:47-52. doi: 10.1016/j.toxicon.2022.01.006.

{slider Doderlin: Isolation and Characterization of a Broad-Spectrum Antimicrobial Peptide from Lactobacillus acidophilus}

Bruna S. da Silva, Andrea Diaz-Roa, Erica S. Yamane, Mirian A.F. Hayashi, Pedro Ismael Silva Junior. Doderlin: Isolation and Characterization of a Broad-Spectrum Antimicrobial Peptide from Lactobacillus acidophilus. bioRxiv 2022.01.19.476933; doi: https://doi.org/10.1101/2022.01.19.476933

{slider Revisting the potential of South American rattlesnake Crotalus durissus terrificus toxins as therapeutic, theranostic and/or biotechnological agents}

Hayashi MAF, Campeiro JD, Yonamine CM. Revisting the potential of South American rattlesnake Crotalus durissus terrificus toxins as therapeutic, theranostic and/or biotechnological agents. Toxicon. Jan 30;206:1-13. doi: https://doi.org/10.1016/j.toxicon.2021.12.005

{slider A native cell-penetrating peptide (CPP) from rattlesnake with therapeutic and theranostic properties}

Porta LC, Campeiro JD, Hayashi MAF. A Native CPP from Rattlesnake with Therapeutic and Theranostic Properties. Methods Mol Biol. 2022;2383:91-104. doi: 10.1007/978-1-0716-1752-6_6.

Read more: Publications in the last 5 years