On October, 13, at 1 pm
Speaker: Ülo Langel, PhD, Dept. Biochemistry and Biophysics, Stockholm University, S-10591 Stockholm, Sweden, Ulo.Langel@dbb.su.se
Moderator: Mirian Hayashi, PhD, associate professor, Department of Pharmacology, Escola Paulista de Medicina - Unifesp
PepFect delivery technology for oligonucleotide transfection by transportan based cell-penetrating peptides in vitro and in vivo is described. Recent data on mechanisms and applications of PepFect strategies are summarized on the variety of different cargoes including plasmid, antisense and siRNA oligonucleotides. Nanomaterials based on cell-penetrating peptides (CPPs) are presented as promising non-viral vectors for gene delivery. The protocol is simple, offers high cell transfection compared to the CPPs-ONs complexes and can be used for further improvements using external stimuli. Possible mechanisms of oligonucleotide delivery by PepFects is discussed and novel data on genome analysis involved in these mechanisms are discussed. Further improvement of these technologies of the modulation of gene expression and identification of novel intracellular interactions in tumors after i.v. administration is discussed, aiming to find novel drug targets, and defining New Chemical Entities for drug development.
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Ülo Langel is a Professor at the Department of Biochemistry and Biophysics, Stockholm University, and at the Institute of Technology, Tartu University. Prof. Langel graduated from Tartu University, Tartu, Estonia, as bioorganic chemist in 1974; he has received his PhD degree twice: in 1980 from Tartu University, Tartu, Estonia (bioorganic chemistry), and in 1993 from Tartu University/Stockholm University (biochemistry/neurochemistry). His professional experience includes a career at Tartu University, Tartu, Estonia (from junior research fellow to Associate Professor, Visiting Professor, and Professor 1974-now); The Scripps Research Institute, La Jolla, CA, USA (Associate Professor, and Adjunct Professor 2000-now); and Stockholm University (from research fellow to Associate Professor, Professor and Chairman, 1987-now). He is a Honorary Professor at Ljubljana University, Slovenia. He was a Chairman of the Board of small companies Pepfex (Stockholm) and Cepep (Estonia) and member of the Board of Orexo (Sweden). In 2013 he was elected a member of Academia Europaea and in 2015, a foreign member of the Estonian Academy of Sciences.
Prof. Langel has been selected as a Fellow Member of International Neuropeptide Society (1995), and is a member of International Society for Neurochemistry, European Peptide Society, Swedish Biochemical Society and Estonian Biochemical Society. He has been awarded a White Star Order, 4th class, by Estonian Republic. He has been invited lecturer at numerous international conferences, and is a coauthor of more than 450 scientific articles and 20 approved or pending patents. His research interest is in neurochemistry where his research is aimed to study peptides, particularly neuropeptide receptors, and in drug delivery by cell-penetrating peptides.
