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Peter Moon | Agência FAPESP – A group of Brazilian researchers has studied in worms the role of genes related to schizophrenia in the response to antipsychotic drugs used in schizophrenic patients. The results obtained so far indicate new ways to understand resistance to certain classes of drugs.

The study is conducted by Profª Drª Mirian Hayashi from the Department of Pharmacology at the Escola Paulista de Medicina of the Universidade Federal de São Paulo (Unifesp) and has the collaboration of researchers from Universidade Estadual de Campinas (Unicamp). An article about the work was published in Progress in Neuro-Psychopharmacology and Biological Psychiatry & Neurochemistry International.

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Read the full publication by Agência FAPESP in this link

The article Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for nuclear distribution element genes (doi: 10.1016/j.neuint.2021.105047), de Joana D'Arc Campeiro, João V Nani, Gabriela Guilherme Monte, Priscila G C Almeida, Marcelo A Mori, Mirian A F Hayashi, can be read at https://www.sciencedirect.com/science/article/abs/pii/S0197018621000930?via%3Dihub.

The article Impact of nuclear distribution element genes in the typical and atypical antipsychotics effects on nematode Caenorhabditis elegans: Putative animal model for studying the pathways correlated to schizophrenia (doi: https://doi.org/10.1016/j.pnpbp.2018.12.010), by Gabriela Guilherme Monte, João V. Nani, Marina Rosseto de Almeida Campos, Caroline Dal Mas, Lucas Augusto Negri Marins, Lucas Gelain Martins, LjubicaTasic, Marcelo A. Moric e Mirian A. F. Hayashi, can be read at www.sciencedirect.com/science/article/pii/S0278584618307036?via%3Dihub.