Embedded Files
Acesse o artigo publicado : Strain-Specific Reduction of Ndel1 Enzymatic Activity During Early Zika Virus Infection in the Neonatal Brain
Strain-Specific Reduction of Ndel1 Enzymatic Activity During Early Zika Virus Infection in the Neonatal Brain
Strain-Specific Reduction of Ndel1 Enzymatic Activity During Early Zika Virus Infection in the Neonatal Brain
Our results demonstrate that Ndel1 downregulation is not a conserved feature of flavivirus infection, nor a universal response to ZIKV, but rather a strain-specific signature of ZIKVBR-induced neuropathogenesis. While both ZIKV strains elicited robust inflammatory and interferon responses, only ZIKVBR infection led to a consistent reduction in Ndel1 enzymatic activity, an effect that was independent of route of infection, dissociated from transcriptional regulation, and not recapitulated by DENV or ZIKVAF under identical experimental conditions.
Increased serum neurodevelopmental biomarker Ndel1 activity in medicated patients with depression is associated with reduced neurite density and neuronal viability independently of intracellular Ndel1 activity
Postnatal Mouse Brain Region-Resolved Peptidomic Resource of Conditional Ndel1 Loss: comparison of acidic and alcoholic extraction strategies
Long-term treatment with haloperidol modulates angiotensin I-converting enzyme (ACE) activity in transgenic animal model with construct validity for schizophrenia studies
RNA-seq transcriptome of ZIKV-infected brain organoids reanalysis implicates Ndel1 oligopeptidase and its cytoskeleton protein binding partners in the infection pathogenesis and recovery following interferon treatment
Blood RNA editing signatures to differentiate patients with schizophrenia and bipolar disorder
An investigation of the sodium nitroprusside effects on serum lipids in an animal model for schizophrenia by magnetic resonance study
Developing a Behavioral Box for Assessing Prepulse Inhibition and Neural Activity in Psychiatric Animal Models
Peering into the mind: unraveling schizophrenia’s secrets using models
Infection by zika virus increase angiotensin I-converting enzyme activity in mouse brain
Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms
Sodium nitroprusside as an adjunctive treatment for schizophrenia reduces the Ndel1 oligopeptidase activity
Identification of an ex vivo inhibitor of the schizophrenia biomarker Ndel1 by high throughput screening
Publicações dos últimos 5 anos
Publicações dos últimos 5 anos
Oyadomari WY, Anthero GL, Silva MRA, Porta LC, Oliveira V, Reid PF, Sant'Anna OA, Alves WA, Nani JV, Hayashi MAF. Evaluation of tumor growth remission in a murine model for subcutaneous solid tumors - Benefits of associating the antitumor agent crotamine with mesoporous nanosilica particles to achieve improved dosing frequency and efficacy. Int J Pharm. 2023;646:123420. doi: 10.1016/j.ijpharm.2023.123420 .
Hayashi MAF, Salvetat N, Cayzac C, Checa-Robles FJ, Dubuc B, Mereuze S, Nani JV, Molina F, Brietzke E, Weissmann D. Euthymic and depressed bipolar patients are characterized by different RNA editing patterns in blood. Psychiatry Res. 2023;328:115422. doi: 10.1016/j.psychres.2023.115422
Christoff RR, Nani JV, Lessa G, Rabello T, Rossi AD, Krenn V, Higa LM, Tanuri A, Garcez PP, Hayashi MAF. Assessing the role of Ndel1 oligopeptidase activity in congenital Zika syndrome: Potential predictor of congenital syndrome endophenotype and treatment response. J Neurochem. 2023;166(4):763-776. doi: 10.1111/jnc.15918
Campeiro JD, Dam WA, Hayashi MAF, van den Born J. Crotamine/siRNA Nanocomplexes for Functional Downregulation of Syndecan-1 in Renal Proximal Tubular Epithelial Cells. Pharmaceutics 2023;15(6):1576. doi: 10.3390/pharmaceutics15061576
de Paula Faria D, D'Arc Campeiro J, de Souza Junqueira M, Real CC, Marques FLN, Hayashi MAF, Sapienza MT. [18F]FDG and [11C]PK11195 PET imaging in the evaluation of brown adipose tissue - effects of cold and pharmacological stimuli and their association with crotamine intake in a male mouse model. Nucl Med Biol. 2023;122-123:108362. doi: 10.1038/s41598-021-93653-3
Boeynaems S, Ma XR, Yeong V, Ginell GM, Chen JH, Blum JA, Nakayama L, Sanyal A, Briner A, Haver DV, Pauwels J, Ekman A, Schmidt HB, Sundararajan K, Porta L, Lasker K, Larabell C, Hayashi MAF, Kundaje A, Impens F, Obermeyer A, Holehouse AS, Gitler AD. Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease. bioRxiv [Preprint]. 2023:2023.03.09.531820. doi: 10.1101/2023.03.09.531820
Santiago TC, Parra L, Nani JV, Fidalgo TM, Bradshaw NJ, Hayashi MAF. Angiotensin-converting enzymes as druggable features of psychiatric and neurodegenerative disorders. J Neurochem. 2023;166(2):138-155. doi: 10.1111/jnc.15806
Correia BSB, de Moraes Pontes JG, Nani JVS, Villalta F, Mor NC, Bordini D, Brunoni D, Brentani H, Mari JJ, Hayashi MAF, Tasic L. 1H NMR Metabolomics and Lipidomics To Monitor Positive Responses in Children with Autism Spectrum Disorder Following a Guided Parental Intervention: A Pilot Study. ACS Chem Neurosci. 2023;14(6):1137-1145. doi: 10.1016/j.nucmedbio.2023.108362
Marins LAN, Rodríguez B, Nani JV, Oliveira V, Gadelha A, Hayashi MAF. Prolyl oligopeptidase activity (POP) in early stage and medicated schizophrenia and in an animal model for schizophrenia study: In vivo effects of psychopharmacological substances on enzyme activity. Brain Disorders, Volume 10, 2023, 100075, ISSN 2666-4593, doi: 10.1016/j.dscb.2023.100075
Moraes VWR, Santos VM, Suarez ER, Ferraz LS, Lopes RM, Mognol GP, Campeiro JD, Machado-Neto JA, Nascimento FD, Hayashi MAF, Tersariol ILS, Newmeyer DD, Rodrigues T. Targeting Ca2+ and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells. Life (Basel). 2022;12(10):1477. doi: 10.3390/life12101477
Nani JV, Almeida PGC, Hayashi MAF. Neuropeptidases in Psychiatric Disorders. In: Encyclopedia of Behavioral Neuroscience, 2nd edition (Second Edition), Editor(s): Sergio Della Sala, Elsevier, 2022, Pages 283-292, ISBN 9780128216361. doi: 10.1016/B978-0-12-819641-0.00091-8.
Nani JV, Almeida PGC, Noto C, Bressan RA, Brietzke E, Hayashi MAF. Unraveiling the correlation among neurodevelopmental and inflammatory biomarkers in patients with chronic schizophrenia. Nord J Psychiatry. 2022;76(7):559-564. doi: 10.1080/08039488.2021.2023217
El Chamy Maluf S, Hayashi MAF, Campeiro JD, Oliveira EB, Gazarini ML, Carmona AK. South American rattlesnake cationic polypeptide crotamine trafficking dynamic in Plasmodium falciparum-infected erythrocytes: Pharmacological inhibitors, parasite cycle and incubation time influences in uptake. Toxicon 2022;208:47-52. doi: 10.1016/j.toxicon.2022.01.006
Hayashi MAF, Campeiro JD, Yonamine CM. Revisiting the potential of South American rattlesnake Crotalus durissus terrificus toxins as therapeutic, theranostic and/or biotechnological agents. Toxicon. 2022;206:1-13. doi: 10.1016/j.toxicon.2021.12.005
Porta LC, Campeiro JD, Hayashi MAF. A Native CPP from Rattlesnake with Therapeutic and Theranostic Properties. Methods Mol Biol. 2022;2383:91-104. doi: 10.1007/978-1-0716-1752-6_6.
Altaf-Ul-Amin M, Hirose K, Nani JV, Porta LC, Tasic L, Hossain SF, Huang M, Ono N, Hayashi MAF, Kanaya S. A system biology approach based on metabolic biomarkers and protein-protein interactions for identifying pathways underlying schizophrenia and bipolar disorder. Sci Rep. 2021;11(1):14450. doi: 10.1038/s41598-021-93653-3.
Campeiro JD, Nani JV, Monte GG, Almeida PGC, Mori MA, Hayashi MAF. Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for nuclear distribution element genes. Neurochem Int. 2021;147:105047. doi: 10.1016/j.neuint.2021.105047
Correia BSB, Nani JV, Waladares Ricardo R, Stanisic D, Costa TBBC, Hayashi MAF, Tasic L. Effects of Psychostimulants and Antipsychotics on Serum Lipids in an Animal Model for Schizophrenia. Biomedicines. 2021;9(3):235. doi: 10.3390/biomedicines9030235
Trombetta-Lima M, Assis-Ribas T, Cintra RC, Campeiro JD, Guerreiro JR, Winnischofer SMB, Nascimento ICC, Ulrich H, Hayashi MAF, Sogayar MC. Impact of Reck expression and promoter activity in neuronal in vitro differentiation. Mol Biol Rep. 2021;48(2):1985-1994. doi.org/10.1007/s11033-021-06175-6
Nani JV, Lee RS, Yonamine CM, Sant'Anna OA, Juliano MA, Gadelha A, Mari JJ, Hayashi MAF. Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics. Sci Rep. 2020;10(1):18513. doi: 10.1038/s41598-020-75616-2.
Maes M, Nani JV, Noto C, Rizzo L, Hayashi MAF, Brietzke E. Impairments in Peripheral Blood T Effector and T Regulatory Lymphocytes in Bipolar Disorder Are Associated with Staging of Illness and Anti-cytomegalovirus IgG Levels. Mol Neurobiol. 2021;58(1):229-242. doi: 10.1007/s12035-020-02110-1
Demais Publicações
Demais Publicações
Nanoparticles in Biology and Medicine doi.org/10.1007/978-1-0716-0319-2
Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics doi.org/10.1038/s41598-020-75616-2
Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine doi.org/10.1007/s00109-020-01975-y
A Study in First-Episode Psychosis Patients: Does Angiotensin I-Converting Enzyme Activity Associated With Genotype Predict Symptom Severity Reductions After Treatment With Atypical Antipsychotic Risperidone? doi.org/10.1093/ijnp/pyaa050
Neuroinflammation and glial cell activation in mental disorders doi.org/10.1016/j.bbih.2019.100034
Impairments in peripheral blood T effector and T regulatory lymphocytes in bipolar disorder are associated with staging of illness and anti-cytomegalovirus IgG levels. scholar.google.co.th/citations?user=1wzMZ7UAAAAJ&hl=th&oi=ao
Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity doi.org/10.1177/0269881119897562
ACE activity in blood and brain axis in an animal model for schizophrenia: effects of dopaminergic manipulation with antipsychotics and psychostimulants https://doi.org/10.1080/15622975.2019.1583372
In vivo effects of the association of the psychoactive phenotiazine thioridazine on antitumor activity and hind limb paralysis induced by the native polypeptide crotamine doi.org/10.1016/j.toxicon.2020.06.017
Neuropeptides and oligopeptidases in schizophrenia doi.org/10.1016/j.neubiorev.2019.11.024
NDE1 and NDEL1 from genes to (mal)functions: parallel but distinct roles impacting on neurodevelopmental disorders and psychiatric illness doi.org/10.1007/s00018-016-2395-7
Long term safety of targeted internalization of cell penetrating peptide crotamine into renal proximal tubular epithelial cells in vivo doi.org/10.1038/s41598-019-39842-7
Insights into the effects of crack abuse on the human metabolome using a NMR approach doi.org/10.1021/acs.jproteome.8b00646
Effects of the Natural Peptide Crotamine from a South American Rattlesnake on Candida auris, an Emergent Multidrug Antifungal Resistant Human Pathogen www.mdpi.com/470012
Oligopeptidases activity in bipolar disorder: Ndel1 and angiotensin I converting enzyme doi.org/10.1016/j.jad.2018.10.001
Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia doi.org/10.1016/j.schres.2019.02.021
Impact of nuclear distribution element genes in the typical and atypical antipsychotics effects on nematode Caenorhabditis elegans: Putative animal model for studying the pathways correlated to schizophrenia doi.org/10.1016/j.pnpbp.2018.12.010
Advances and challenges in development of precision psychiatry through clinical metabolomics on mood and psychotic disorders doi.org/10.1016/j.pnpbp.2019.03.010
Peripheral biomarkers allow differential diagnosis between schizophrenia and bipolar disorder doi.org/10.1016/j.jpsychires.2019.09.009
Oral treatment with a rattlesnake native polypeptide crotamine efficiently inhibits the tumor growth with no potential toxicity for the host animal and with suggestive positive effects on animal metabolic profile doi.org/10.1007/s00726-017-2513-3
Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles doi.org/10.1371/%20journal.pntd.0006700
Crotamine induces browning of adipose tissue and increases energy expenditure in mice doi.org/10.1038/s41598-018-22988-1
Tryptophan Metabolism in mental disorders: A Focus on Schizophrenia doi.org/10.14295/vittalle.v29i2.6550
Biophysical and biological properties of small linear peptides derived from crotamine, a cationic antimicrobial/antitumoral toxin with cell penetrating and cargo delivery abilities dx.doi.org/10.1016/j.bbamem.2017.09.006
Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis doi.org/10.1038/tp.2016.159
A preliminary study of bipolar disorder type I by mass spectrometry-based serum lipidomics dx.doi.org/10.1016/j.psychres.2017.08.039
Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders doi.org/10.1515/revneuro-2017-0001
1H-NMR, 1H-NMR T2-edited, and 2D-NMR in bipolar disorder metabolic profiling doi.org/10.1186/s40345-017-0088-2
ANALYTICAL APPROACHES FOR LIPIDOMICS AND ITS POTENTIAL APPLICATIONS IN NEUROPSYCHIATRIC DISORDERS dx.doi.org/10.3109/15622975.2015.1117656
Metabolomics and lipidomics analyses by 1H nuclear magnetic resonance of schizophrenia patient serum reveal potential peripheral biomarkers for diagnosis dx.doi.org/10.1016/j.schres.2016.12.024
Anthelmintic effects of a cationic toxin from a South American rattlesnake venom dx.doi.org/10.1016/j.toxicon.2015.11.021
Inhibition of malaria parasite Plasmodium falciparum development by crotamine, a cell penetrating peptide from the snake venom dx.doi.org/doi:10.1016/j.peptides.2016.01.013
Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity dx.doi.org/10.1016/j.schres.2016.01.043
Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis dx.doi.org/10.1016/j.euroneuro.2015.09.013
Page updated
Report abuse