Alunos

João Victor Silva Nani

DOUTORADO

Joao

PROJETO:

Estudo do(s) mecanismo(s) celular(es) e molecular(es) dos transtornos mentais

CAPES-PRINT - Queen's University, Kingston, Canada

CV LATTES

Joao

Lattes

Bolsista de Doutorado da FAPESP

Possui graduação em Ciências Biológicas pela Universidade Federal de São Paulo (2016) e mestrado em Psiquiatria e Psicologia Médica pela Universidade Federal de São Paulo (2018). Atualmente no doutorado pelo programa de Farmacologia na Universidade Federal de São Paulo. Tem experiência na área de Farmacologia, com ênfase em Farmacologia Bioquímica e Molecular, atuando principalmente nos seguintes temas: modelo animal, esquizofrenia, neurodesenvolvimento e oligopeptidases.

PUBLICAÇÕES

Checa-Robles FJ, Salvetat N, Cayzac C, Menhem M, Favier M, Vetter D, Ouna I, Nani JV, Hayashi MAF, Brietzke E, Weissmann D. RNA Editing Signatures Powered by Artificial Intelligence: A New Frontier in Differentiating Schizophrenia, Bipolar, and Schizoaffective Disorders. Int J Mol Sci. 2024 Dec 3;25(23):12981. doi: 10.3390/ijms252312981.
Pontes JGM, Nani JVS, Correia BSB, Carneiro Costa TBB, Stanisic D, Hayashi MAF, Tasic L. An Investigation of the Sodium Nitroprusside Effects on Serum Lipids in an Animal Model of Schizophrenia by the Magnetic Resonance Study. ACS Omega. 2024 Nov 25;9(49):48480-48487. doi: 10.1021/acsomega.4c07072.
Nani JV, Muotri AR, Hayashi MAF. Peering into the mind: unraveling schizophrenia's secrets using models. Mol Psychiatry. 2024 Sep 8. doi: 10.1038/s41380-024-02728-w. Epub ahead of print.
Oyadomari WY, Anthero GL, Silva MRA, Porta LC, Oliveira V, Reid PF, Sant'Anna OA, Alves WA, Nani JV, Hayashi MAF. Evaluation of tumor growth remission in a murine model for subcutaneous solid tumors - Benefits of associating the antitumor agent crotamine with mesoporous nanosilica particles to achieve improved dosing frequency and efficacy. Int J Pharm. 2023 Nov 5;646:123420. doi: 10.1016/j.ijpharm.2023.123420.
Courchesne E, Taluja V, Nazari S, Aamodt CM, Pierce K, Duan K, Stophaeros S, Lopez L, Barnes CC, Troxel J, Campbell K, Wang T, Hoekzema K, Eichler EE, Nani JV, Pontes W, Sanchez SS, Lombardo MV, de Souza JS, Hayashi MAF, Muotri AR. Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms. Mol Autism. 2024 May 25;15(1):22. doi: 10.1186/s13229-024-00602-8.
Nani JV, Ushirohira JM, Bradshaw NJ, Machado-de-Sousa JP, Hallak JEC, Hayashi MAF. Sodium nitroprusside as an adjunctive treatment for schizophrenia reduces the Ndel1 oligopeptidase activity. Braz J Psychiatry. 2023 Nov 23. doi: 10.47626/1516-4446-2023-3315.
Nani JV, Coelho C, Oyadomari WY, Santiago TC, Machado MM, Christoff RR, Garcez PP, Oliveira V, Würtele M, Hayashi MAF. Identification of an ex vivo inhibitor of the schizophrenia biomarker Ndel1 by high throughput screening. Biochem Pharmacol. 2023 Nov;217:115841. doi: 10.1016/j.bcp.2023.115841.
Oyadomari WY, Anthero GL, Silva MRA, Porta LC, Oliveira V, Reid PF, Sant'Anna OA, Alves WA, Nani JV, Hayashi MAF. Evaluation of tumor growth remission in a murine model for subcutaneous solid tumors - Benefits of associating the antitumor agent crotamine with mesoporous nanosilica particles to achieve improved dosing frequency and efficacy. Int J Pharm. 2023 Nov 5;646:123420. doi: 10.1016/j.ijpharm.2023.123420.
Hayashi MAF, Salvetat N, Cayzac C, Checa-Robles FJ, Dubuc B, Mereuze S, Nani JV, Molina F, Brietzke E, Weissmann D. Euthymic and depressed bipolar patients are characterized by different RNA editing patterns in blood. Psychiatry Res. 2023 Oct;328:115422. doi: 10.1016/j.psychres.2023.115422.
Christoff RR, Nani JV, Lessa G, Rabello T, Rossi AD, Krenn V, Higa LM, Tanuri A, Garcez PP, Hayashi MAF. Assessing the role of Ndel1 oligopeptidase activity in congenital Zika syndrome: Potential predictor of congenital syndrome endophenotype and treatment response. J Neurochem. 2023 Aug;166(4):763-776. doi: 10.1111/jnc.15918.
Santiago TC, Parra L, Nani JV, Fidalgo TM, Bradshaw NJ, Hayashi MAF. Angiotensin-converting enzymes as druggable features of psychiatric and neurodegenerative disorders. J Neurochem. 2023 Jul;166(2):138-155. doi: 10.1111/jnc.15806.
Correia BSB, de Moraes Pontes JG, Nani JVS, Villalta F, Mor NC, Bordini D, Brunoni D, Brentani H, Mari JJ, Hayashi MAF, Tasic L. 1H NMR Metabolomics and Lipidomics To Monitor Positive Responses in Children with Autism Spectrum Disorder Following a Guided Parental Intervention: A Pilot Study. ACS Chem Neurosci. 2023 Mar 15;14(6):1137-1145. doi: 10.1021/acschemneuro.2c00735.
Nani JV, Almeida PGC, Noto C, Bressan RA, Brietzke E, Hayashi MAF. Unraveiling the correlation among neurodevelopmental and inflammatory biomarkers in patients with chronic schizophrenia. Nord J Psychiatry. 2022 Oct;76(7):559-564. doi: 10.1080/08039488.2021.2023217.
Altaf-Ul-Amin M, Hirose K, Nani JV, Porta LC, Tasic L, Hossain SF, Huang M, Ono N, Hayashi MAF, Kanaya S. A system biology approach based on metabolic biomarkers and protein-protein interactions for identifying pathways underlying schizophrenia and bipolar disorder. Sci Rep. 2021 Jul 14;11(1):14450. doi: 10.1038/s41598-021-93653-3.
Campeiro JD, Nani JV, Monte GG, Almeida PGC, Mori MA, Hayashi MAF. Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for nuclear distribution element genes. Neurochem Int. 2021 Apr 17;147:105047. doi: 10.1016/j.neuint.2021.105047.
Correia BSB, Nani JV, Waladares Ricardo R, Stanisic D, Costa TBBC, Hayashi MAF, Tasic L. Effects of psychostimulants and antipsychotics on serum lipids in an animal model for schizophrenia. Biomedicines. 2021 Feb 26;9(3):235. doi: 10.3390/biomedicines9030235.
Nani JV, Lee RS, Yonamine CM, Sant'Anna OA, Juliano MA, Gadelha A, Mari JJ, Hayashi MAF. Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics. Sci Rep. 2020 Oct 28;10(1):18513. doi: 10.1038/s41598-020-75616-2.
Maes M, Nani JV, Noto C, Rizzo L, Hayashi MAF, Brietzke E. Impairments in Peripheral Blood T Effector and T Regulatory Lymphocytes in Bipolar Disorder Are Associated with Staging of Illness and Anti-cytomegalovirus IgG Levels. Mol Neurobiol. 2021 Jan;58(1):229-242. doi: 10.1007/s12035-020-02110-1.
Nani JV, Dal Mas C, Yonamine CM, Ota VK, Noto C, Belangero SI, Mari JJ, Bressan R, Cordeiro Q, Gadelha A, Hayashi MAF. A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone?. Int J Neuropsychopharmacol. 2020 Jul 22;23(11):721-30. doi: 10.1093/ijnp/pyaa050.
Nani JV, Fonseca MC, Engi SA, Perillo MG, Dias CS, Gazarini ML, Korth C, Cruz FC, Hayashi MA. Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity. J Psychopharmacol. 2020 Apr;34(4):467-477. doi: 10.1177/0269881119897562
Rodríguez B, Nani JV, Almeida PGC, Brietzke E, Lee RS, Hayashi MAF. Neuropeptides and oligopeptidases in schizophrenia. Neurosci Biobehav Rev. 2020 Jan;108:679-693. doi: 10.1016/j.neubiorev.2019.11.024.
Tasic L, Larcerda ALT, Pontes JGM, da Costa TBBC, Nani JV, Martins LG, Santos LA, Nunes MFQ, Adelino MPM, Pedrini M, Cordeiro Q, Bachion de Santana F, Poppi RJ, Brietzke E, Hayashi MAF. Peripheral biomarkers allow differential diagnosis between schizophrenia and bipolar disorder. J Psychiatr Res. 2019 Dec;119:67-75. doi: 10.1016/j.jpsychires.2019.09.009.
Pedrini M, Cao B, Nani JVS, Cerqueira RO, Mansur RB, Tasic L, Hayashi MAF, McIntyre RS, Brietzke E. Advances and challenges in development of precision psychiatry through clinical metabolomics on mood and psychotic disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13;93:182-188. doi: 10.1016/j.pnpbp.2019.03.010.
Dal Mas C, Nani JV, Noto C, Yonamine CM, da Cunha GR, Mansur RB, Ota VK, Belangero SI, Cordeiro Q, Kapczinski F, Brietzke E, Bressan RA, Gadelha A, Hayashi MAF. Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia. Schizophr Res. 2019 Jun;208:202-208. doi: 10.1016/j.schres.2019.02.021.
Nani JV, Yonamine CM, Castro Musial D, Dal Mas C, Mari JJ, Hayashi MAF. ACE activity in blood and brain axis in an animal model for schizophrenia: Effects of dopaminergic manipulation with antipsychotics and psychostimulants. World J Biol Psychiatry. 26:1-11. 2019. doi: 10.1080/15622975.2019.1583372.
Monte GG, Nani JV, de Almeida Campos MR, Dal Mas C, Marins LAN, Martins LG, Tasic L, Mori MA, Hayashi MAF. Impact of nuclear distribution element genes in the typical and atypical antipsychotics effects on nematode Caenorhabditis elegans: Putative animal model for studying the pathways correlated to schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 92:19-30. 2019. doi: 10.1016/j.pnpbp.2018.12.010.

Joana D'Arc Campeiro

DOUTORADO

Joana

PROJETO:

Uso da crotamina, um peptídeo célula penetrante como carregador de genes para terapia da

disfunção renal

COTUTELA DOUTORADO - Use of crotamine as a gene carrier for renal dysfunction therapy (University of Groningen, Groningen, The Netherlands)

CV LATTES

Joana

Lattes

Bolsista de Doutorado da CAPES - sanduíche na University Medical Center Groningen (Orientador: Jaap van den Born)

Bachelor's at Pharmacy biochemistry. Universidade de São Paulo, USP, São Paulo, Brazil (2011). Master's in Pharmacology. Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil - Advisor: Mirian Akemi Furuie Hayashi (2014-2015). Doctorate in progress in Pharmacology. Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil / University of Groningen (The Netherlands) Advisor: Mirian Akemi Furuie Hayashi /Jaap van den Born (2016-XX). Clinical Research Assistant - Quintiles Transnational (2009-2012).

PUBLICAÇÕES

Campeiro JD, Dam WA, Hayashi MAF, van den Born J. Crotamine/siRNA Nanocomplexes for Functional Downregulation of Syndecan-1 in Renal Proximal Tubular Epithelial Cells. Pharmaceutics. 2023 May 23;15(6):1576. doi: 10.3390/pharmaceutics15061576.
Moraes VWR, Santos VM, Suarez ER, Ferraz LS, Lopes RM, Mognol GP, Campeiro JD, Machado-Neto JA, Nascimento FD, Hayashi MAF, Tersariol ILS, Newmeyer DD, Rodrigues T. Targeting Ca²⁺ and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells. Life (Basel). 2022 Sep 23;12(10):1477. doi: 10.3390/life12101477.
El Chamy Maluf S, Hayashi MAF, Campeiro JD, Oliveira EB, Gazarini ML, Carmona AK. South American rattlesnake cationic polypeptide crotamine trafficking dynamic in Plasmodium falciparum-infected erythrocytes: Pharmacological inhibitors, parasite cycle and incubation time influences in uptake. Toxicon. 2022 Mar;208:47-52. doi: 10.1016/j.toxicon.2022.01.006.
Hayashi MAF, Campeiro JD, Yonamine CM. Revisiting the potential of South American rattlesnake Crotalus durissus terrificus toxins as therapeutic, theranostic and/or biotechnological agents. Toxicon. 2022 Jan 30;206:1-13. doi: 10.1016/j.toxicon.2021.12.005.
Porta LC, Campeiro JD, Hayashi MAF. A Native CPP from Rattlesnake with Therapeutic and Theranostic Properties. Methods Mol Biol. 2022;2383:91-104. doi: 10.1007/978-1-0716-1752-6_6.
Campeiro JD, Nani JV, Monte GG, Almeida PGC, Mori MA, Hayashi MAF. Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for nuclear distribution element genes. Neurochem Int. 2021 Apr 17;147:105047. doi: 10.1016/j.neuint.2021.105047.
Trombetta-Lima M, Assis-Ribas T, Cintra RC, Campeiro JD, Guerreiro JR, Winnischofer SMB, Nascimento ICC, Ulrich H, Hayashi MAF, Sogayar MC. Impact of Reck expression and promoter activity in neuronal in vitro differentiation. Mol Biol Rep. 2021 Feb;48(2):1985-1994. doi: 10.1007/s11033-021-06175-6
de Carvalho Porta L, Fadel V, D'Arc Campeiro J, Oliveira EB, Godinho RO, Hayashi MAF. Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine. J Mol Med (Berl). 2020 Nov;98(11):1561-1571. doi: 10.1007/s00109-020-01975-y.
Porta LC, Campeiro JD, Papa GB, Oliveira EB, Godinho RO, Rodrigues T, Hayashi MAF. In vivo effects of the association of the psychoactive phenotiazine thioridazine on antitumor activity and hind limb paralysis induced by the native polypeptide crotamine. Toxicon 2020 Oct 15;185:64-71. doi: 10.1016/j.toxicon.2020.06.017
Hayashi MAF, Campeiro JD, Porta LC, Szychowski B, Alves WA, Oliveira EB, Kerkis I, Daniel MC, Karpel RL. (2020) Crotamine Cell-Penetrating Nanocarriers: Cancer-Targeting and Potential Biotechnological and/or Medical Applications. Methods Mol Biol. 2020;2118:61-89. doi: 10.1007/978-1-0716-0319-2_5
Campeiro JD, Dam W, Monte GG, Porta LC, Oliveira LCG, Nering MB, Viana GM, Carapeto FC, Oliveira EB, van den Born J, Hayashi MAF. Long term safety of targeted internalization of cell penetrating peptide crotamine into renal proximal tubular epithelial cells in vivo. Sci Rep. 2019 Mar 1;9(1):3312. doi: 10.1038/s41598-019-39842-7.
Lima SC, Porta LC, Lima ÁDC, Campeiro JD, Meurer Y, Teixeira NB, Duarte T, Oliveira EB, Picolo G, Godinho RO, Silva RH, Hayashi MAF. Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles. PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006700. doi: doi: 10.1371/journal.pntd.0006700.
Marinovic MP, Campeiro JD, Lima SC, Rocha AL, Nering MB, Oliveira EB, Mori MA, Hayashi MAF. Crotamine induces browning of adipose tissue and increases energy expenditure in mice. Sci Rep. 2018 Mar 22;8(1):5057. doi: 10.1038/s41598-018-22988-1.
Karpel RL, da Silva Liberato M, Campeiro JD, Bergeon L, Szychowski B, Butler A, Marino G, Cusic JF, de Oliveira LCG, Oliveira EB, de Farias MA, Portugal RV, Alves WA, Daniel MC, Hayashi MAF. Design and characterization of crotamine-functionalized gold nanoparticles. Colloids Surf B Biointerfaces. 2018 Mar 1;163:1-8. doi:10.1016/j.colsurfb.2017.12.013.
Dal Mas C, Pinheiro DA, Campeiro JD, Mattei B, Oliveira V, Oliveira EB, Miranda A, Perez KR, Hayashi MAF. Biophysical and biological properties of small linear peptides derived from crotamine, a cationic antimicrobial/antitumoral toxin with cell penetrating and cargo delivery abilities. Biochim Biophys Acta Biomembr. 2017 Dec;1859(12):2340-2349. doi: 10.1016/j.bbamem.2017.09.006.
Campeiro JD, Marinovic MP, Carapeto FC, Dal Mas C, Monte GG, Carvalho Porta L, Nering MB, Oliveira EB, Hayashi MAF. Oral treatment with a rattlesnake native polypeptide crotamine efficiently inhibits the tumor growth with no potential toxicity for the host animal and with suggestive positive effects on animal metabolic profile. Amino Acids. 2018 Feb;50(2):267-278. doi: 10.1007/s00726-017-2513-3.
Marinovic M.P., Dal Mas C., Monte G.G., Felix D., Campeiro J.D., Hayashi M.A.F. (2016) Crotamine: Function Diversity and Potential Applications. In: Gopalakrishnakone P., Inagaki H., Mukherjee A., Rahmy T., Vogel CW. (eds) Snake Venoms. Toxinology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6648-8_28-1
Campeiro JD, Neshich IP, Sant'Anna OA, Lopes R, Ianzer D, Assakura MT, Neshich G, Hayashi MAF. Identification of snake bradykinin-potentiating peptides (BPPs)-simile sequences in rat brain--Potential BPP-like precursor protein? Biochem Pharmacol. 2015 Aug 1;96(3):202-15. doi: 10.1016/j.bcp.2015.05.012.
Hayashi MA, Guerreiro JR, Charych E, Kamiya A, Barbosa RL, Machado MF, Campeiro JD, Oliveira V, Sawa A, Camargo AC, Brandon NJ. Identification of snake bradykinin-potentiating peptides (BPPs)-simile sequences in rat brain – Potential BPP-like precursor protein?Mol Cell Neurosci. 2010 Aug;44(4):353-61. doi: 10.1016/j.mcn.2010.04.006.

Daniel Oliveira Pires de Moraes

Gabriel Lessa Anthero

MESTRADO

Gabriel

PROJETO: ANÁLISE DA ATIVIDADE DA NDEL1 EM MODELOS ANIMAIS COM ALTERAÇÕES NO PROCESSO DE MIGRAÇÃO E POSICIONAMENTO NEURONAL

CV LATTES

Gabriel

Lattes

Bolsista de Mestrado do CAPES

Graduado em Ciências Biológicas na Universidade Federal do Rio de Janeiro no Instituto de sustentabilidade e diversidade (Nupem). Diretor de Comunicação da Liga de Neurociências da UFRJ-Macaé (2020-2022). Monitor da disciplina de Biologia tecidual (2019). Realizou iniciação científica em estudo de neuroproteção por exposição de cafeína em células de Neuroblastoma Humano (SH-SY5Y) com injúria por Paraquat (2018-2019). Desenvolveu iniciação científica no estudo da Nanotecnologia de aplicação de extratos de Ascídias em exposição em células de Neuroblastoma de Murino (2020).Atuou no Projeto de extensão Corpo Humano em ação (2017-2022). Representante Discente da Comissão de acompanhamento acadêmico do curso de Ciências biológicas (período 2018-2020). Diretor de ensino e extensão da União brasileira de ligas acadêmicas de Neurociências (UBLAN). Mestrando do Programa em Farmacologia da Universidade Federal de São Paulo (UNIFESP) com o projeto intitulado Análise da atividade da Ndel1 em modelos animais com alterações no neurodesenvolvimento. Trabalha também com estudos farmacológicos da administração oral da crotamina, uma toxina isolada da peçonha da cascavel em conjunto com a nanosílica SBA15 em camundongos acometidos com tumor, a fim de observar a remissão da massa tumoral neste modelo animal.

PUBLICAÇÕES

Oyadomari WY, Anthero GL, Silva MRA, Porta LC, Oliveira V, Reid PF, Sant'Anna OA, Alves WA, Nani JV, Hayashi MAF. Evaluation of tumor growth remission in a murine model for subcutaneous solid tumors - Benefits of associating the antitumor agent crotamine with mesoporous nanosilica particles to achieve improved dosing frequency and efficacy. Int J Pharm. 2023 Nov 5;646:123420. doi: 10.1016/j.ijpharm.2023.123420.
Christoff RR, Nani JV, Lessa G, Rabello T, Rossi AD, Krenn V, Higa LM, Tanuri A, Garcez PP, Hayashi MAF. Assessing the role of Ndel1 oligopeptidase activity in congenital Zika syndrome: Potential predictor of congenital syndrome endophenotype and treatment response. J Neurochem. 2023 Aug;166(4):763-776. doi: 10.1111/jnc.15918.

Ananda Luiza Andrade Silva

INICIAÇÃO CIENTÍFICA
CV LATTES

INICIAÇÃO CIENTÍFICA

ananda

PROJETO: Análise da atividade da enzima conversora da angiotensina I em modelo animal com posicionamento neuronal alterado

Maria Clara Ferreira Camargo

TT-3 FAPESP
CV LATTES

TT-3 FAPESP

Maria Clara

PROJETO: ANÁLISE BIOQUÍMICA DE CAMUNDONGOS NOCAUTES CONDICIONAL PARA NDEL1

CV LATTES

Maria Clara

LATTES

Possui graduação em Farmácia pela Universidade Federal de Alfenas (2022). Atuou como auxiliar de farmácia na instituição Hospital de Clínicas Antônio Afonso (2022). Foi farmacêutica na empresa Droga Raia-Grupo RD (2022) e na empresa Terapêutica Farmácia de Manipulação (2023). Tem experiência na área de assistência farmacêutica ao paciente, atendimento farmacêutico magistral comercial, manipulação de medicamentos e realização de serviços farmacêuticos como aplicação de injetáveis, aferição de pressão, testes de glicemia e perfuração de lóbulo.

Priscila Gasperini Camolesi de Almeida

MESTRADO

pri circulo

PROJETO: Análise bioquímica e morfológica de células neuronais visando o estudo molecular e celular de processos envolvidos na esquizofrenia

CV LATTES

pri circulo

LATTES

Bolsista de Mestrado da CAPES

Graduada em Ciências Biomédicas pela Universidade Estadual Paulista "Júlio de Mesquita Fillho", com iniciação científica financiada pela FAPESP, processo 2017/25982-1, sob orientação do Prof. Dr. Erick José Ramo da Silva. Atualmente aluna de mestrado pelo programa de Farmacologia da Universidade Federal de São Paulo - Escola Paulista de Medicina, sobre orientação da Profa. Dra. Mirian Akemi Furuie Hayashi.

PUBLICAÇÕES

Nani JV, Almeida PGC, Noto C, Bressan RA, Brietzke E, Hayashi MAF. Unraveiling the correlation among neurodevelopmental and inflammatory biomarkers in patients with chronic schizophrenia. Nord J Psychiatry. 2022 Oct;76(7):559-564. doi: 10.1080/08039488.2021.2023217.
Campeiro JD, Nani JV, Monte GG, Almeida PGC, Mori MA, Hayashi MAF. Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for nuclear distribution element genes. Neurochem Int. 2021 Apr 17;147:105047. doi: 10.1016/j.neuint.2021.105047.
ALMEIDA, PRISCILA G.C.; NANI, JOÃO VICTOR ; OSES, JEAN PIERRE ; BRIETZKE, ELISA ; HAYASHI, MIRIAN A.F. Neuroinflammation and glial cell activation in mental disorders. Brain, Behavior, & Immunity - Health, v. 2, p. 100034, 2020. https://doi.org/10.1016/j.bbih.2019.1
RODRÍGUEZ, BENJAMÍN ; NANI, JOÃO VICTOR ; ALMEIDA, PRISCILA G.C. ; BRIETZKE, ELIZA ; LEE, RICHARD S. ; HAYASHI, MIRIAN A.F. . NEUROPEPTIDES AND OLIGOPEPTIDASES IN SCHIZOPHRENIA. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 108, p. 679-693, 2019. https://doi.org/10.1016/j.neubiorev.2019.11.024

Thays Calista Santiago

MESTRADO

Thays

PROJETO: AVALIAÇÃO DA ATIVIDADE DA ENZIMA CONVERSORA DA ANGIOTENSINA 1 (ECA1) EM RATOS TRANSGÊNICOS QUE SUPEREXPRESSAM A DISC1 HUMANA ÍNTEGRA

CV LATTES

Thays

Lattes

Bolsista de Mestrado do CNPq

Estágio: Laboratorista - Universidade de Mogi das Cruzes (2019); Estágio: Monitora de Conteúdo - Museu de Ciências Catavento (2019); Bacharelado em Química - Universidade de Mogi das Cruzes (2020); Professora Particular de Ciências Exatas e Naturais - Monitorias (2020); Estudante do Departamento de Farmacologia - Universidade Federal de São Paulo (2021).

PUBLICAÇÕES

Nani JV, Coelho C, Oyadomari WY, Santiago TC, Machado MM, Christoff RR, Garcez PP, Oliveira V, Würtele M, Hayashi MAF. Identification of an ex vivo inhibitor of the schizophrenia biomarker Ndel1 by high throughput screening. Biochem Pharmacol. 2023 Nov;217:115841. doi: 10.1016/j.bcp.2023.115841.
Santiago TC, Parra L, Nani JV, Fidalgo TM, Bradshaw NJ, Hayashi MAF. Angiotensin-converting enzymes as druggable features of psychiatric and neurodegenerative disorders. J Neurochem. 2023 Jul;166(2):138-155. doi: 10.1111/jnc.15806.

Camila M Yonamine

PÓS-DOUTORADO

Camila

PROJETO: Estudo das oligopeptidases na esquizofrenia

BEPE/FAPESP - Pós-Doutorado (Structural Genomics Consortium Oxford, Oxford, UK)

CV LATTES

Camila

Lattes ID Lattes: 0102920590253419

Bolsista de Pós-Doutorado FAPESP

Graduate at Biologia from Universidade Presbiteriana Mackenzie (2004) and master's at Aplicacões Em Tecnologia Nuclear from Instituto de Pesquisas Energéticas Nucleares (2007). Has experience in Pharmacology, focusing on Pharmacology, acting on the following subjects: phoneutria nigriventer, toxin, spider, nitric oxide synthase and biodistribution.

PUBLICAÇÕES

1. DAL MAS, CAROLINE ; CARVALHO, MICHELLE S. ; MARINS, LUCAS A. ; Yonamine, Camila M. ; CORDEIRO, QUIRINO ; MCINTYRE, ROGER S. ; MANSUR, RODRIGO B. ; BRIETZKE, ELISA ; Hayashi, Mirian A.F. . Oligopeptidases activity in bipolar disorder: Ndel1 and angiotensin I converting enzyme. JOURNAL OF AFFECTIVE DISORDERS, v. 244, p. 67-70, 2019.

2. Carvalho MS ; MAS, C. D. ; NUNES, D. F. S. ; YONAMINE, C. M. ; HAYASHI, M. A. F. . METABOLISMO DO TRIPTOFANO EM TRANSTORNOS MENTAIS: UM ENFOQUE NA ESQUIZOFRENIA. Vittalle, v. 29, p. 44-56, 2017.

3. GADELHA, ARY ; COLEMAN, JONATHAN ; BREEN, GEROME ; MAZZOTI, DIEGO ROBLES ; Yonamine, Camila M. ; PELLEGRINO, RENATA ; OTA, VANESSA KIYOMI ; BELANGERO, SINTIA IOLE ; GLESSNER, JOSEPH ; SLEIMAN, PATRICK ; HAKONARSON, HAKON ; Hayashi, Mirian A.F. ; BRESSAN, RODRIGO A. . Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity. SCHIZOPHRENIA RESEARCH, v. 172, p. 60-67, 2016.

4. HAYASHI, M.A.F. ; FELICORI, L.F. ; FRESQUI, M.A.C. ; YONAMINE, C.M. . Protein-Protein and Peptide-Protein Interactions of NudE-Like 1 (Ndel1): A Protein Involved in Schizophrenia. Current Protein and Peptide Science, v. 16, p. 754-767, 2015.

5. GADELHA, ARY ; Yonamine, Camila M. ; NERING, MARCELA ; RIZZO, LUCAS BORTOLOTTO ; NOTO, CRISTIANO ; COGO-MOREIRA, HUGO ; TEIXEIRA, ANTÔNIO LÚCIO ; BRESSAN, RODRIGO ; MAES, MICHAEL ; BRIETZKE, ELISA ; Hayashi, Mirian A.F. . Angiotensin converting enzyme activity is positively associated with IL-17a levels in patients with schizophrenia. Psychiatry Research (Print), v. 229, p. 702-707, 2015.

6. GADELHA, ARY ; Yonamine, Camila M. ; OTA, VANESSA K. ; Oliveira, Vitor ; SATO, JOÃO RICARDO ; BELANGERO, SINTIA I. ; BRESSAN, RODRIGO A. ; Hayashi, Mirian A.F. . ACE I/D genotype-related increase in ACE plasma activity is a better predictor for schizophrenia diagnosis than the genotype alone. Schizophrenia Research (Print), v. 164, p. 109-114, 2015.

7. Yonamine, Camila M. ; Kondo, Marcia Y. ; NERING, MARCELA B. ; GOUVÊA, IURI E. ; OKAMOTO, DÉBORA ; ANDRADE, DOUGLAS ; DA SILVA, JOSÉ ALBERTO A. ; PRIETO DA SILVA, ÁLVARO R.B. ; YAMANE, Tetsuo ; Juliano, Maria A. ; JULIANO, LUIZ ; Lapa, Antônio J. ; Hayashi, Mirian A.F. ; Lima-Landman, Maria Teresa R. . Enzyme specificity and effects of gyroxin, a serine protease from the venom of the South American rattlesnake Crotalus durissus terrificus, on protease-activated receptors. Toxicon (Oxford), v. 79, p. 64-71, 2014.

8. Miyagui, Camila ; Brando Prieto da Silva, lvaro Rossan de ; Santana, Geraldo . Serine proteases: Cloning, Expression and Potential Applications. An Integrated View of the Molecular Recognition and Toxinology - From Analytical Procedures to Biomedical Applications. 1 ed. : InTech, 2013, v. , p. 153-173.

9. GADELHA, ARY ; MACHADO, MAURICIO F.M. ; Yonamine, Camila M. ; SATO, JOÃO R. ; Juliano, Maria A. ; Oliveira, Vitor ; BRESSAN, RODRIGO A. ; Hayashi, Mirian A.F. . Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia - A potential biomarker?. Journal of Psychiatric Research, v. 47, p. 657-663, 2013.

10. Yonamine, Camila M. ; Kondo, Marcia Y. ; Juliano, Maria A. ; Icimoto, Marcelo Y. ; Baptista, Gandhi R. ; YAMANE, Tetsuo ; Oliveira, Vitor ; Juliano, Luis ; Lapa, Antônio J. ; Lima-Landman, Maria Teresa R. ; Hayashi, Mirian A.F. . Kinetic characterization of gyroxin, a serine protease from Crotalus durissus terrificus venom. Biochimie (Paris. Print), v. x, p. 1-3, 2012.

11. BAPTISTA, J. A. ; Vieira, D.P ; GALISTEO JUNIOR, A. J. ; HIGA, Olga Zazuco ; CASARE, Murilo da Silva ; YONAMINE, C. M. ; CAPRONI, P. ; Campos, L.A ; Andrade Júnior, H.F ; SPENCER, P. J. ; NASCIMENTO, N. . Structure alteration and immunological properties of 60Co-gamma-rays irradiated bothropstoxin-I. Journal of Radioanalytical and Nuclear Chemistry (Print), v. 283, p. 691-698, 2010.

12. YONAMINE, C. M. ; Prieto-da-Silva, A.R.B. ; Magalhães, G.S. ; Rádis-Baptista, G. ; Morganti, L. ; Ambiel, F.C. ; Chura-Chambi, R.M. ; Yamane, T. ; Camillo, M.A.P. . Cloning of serine protease cDNAs from Crotalus durissus terrificus venom gland and expression of a functional Gyroxin homologue in COS-7 cells. Toxicon (Oxford), v. 54, p. 110-120, 2009.

13. YONAMINE, C. M. ; COSTA, Helena ; SILVA, José Alberto Alves da ; MURAMOTO, Emiko ; ROGERO, José Roberto ; TRONCONE, L R P ; Camillo, M.A.P. . BIODISTRIBUTION STUDIES OF BEE VENOM AND SPIDER TOXIN USING RADIOTRACERS. The Journal of Venomous Animals and Toxins Including Tropical Diseases (Online), v. 11, p. 39-50, 2005.

14. YONAMINE, C. M. ; TRONCONE, Lanfranco Ranieri Paolo ; CAMILLO, Maria Aparecida Pires . Blockade of neuronal nitric oxide synthase abolishes the toxic effects of Tx2-5, a lethal Phoneutria nigriventer spider toxin. Toxicon (Oxford), Inglaterra, v. 44, p. 169-172, 2004.

Lucas de Carvalho Porta

DOUTORADO

lucas circulo

PROJETO:

Efeitos inesperados da pandemia por covid-19: avaliação de possíveis efeitos e consequências em transtornos mentais

CAPES-PRINT - Gitler lab - Stanford University, Stanford, CA, USA

PUBLICAÇÕES

de CARVALHO PORTA, L. C., FADEL, V., CAMPEIRO, J. D., OLIVEIRA, E. B., GODINHO, R. O., & HAYASHI, M. (2020) Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine. J Mol Med (Berl). 98(11):1561-1571. doi: 10.1007/s00109-020-01975-y.
PORTA, L. C., CAMPEIRO, J. D., PAPA, G. B., OLIVEIRA, E. B., GODINHO, R. O., RODRIGUES, T., & HAYASHI, M. (2020) In vivo effects of the association of the psychoactive phenotiazine thioridazine on antitumor activity and hind limb paralysis induced by the native polypeptide crotamine. Toxicon 185, 64-71. https://doi.org/10.1016/j.toxicon.2020.06.017
HAYASHI, M., CAMPEIRO, J. D., PORTA, L. C., SZYCHOWSKI, B., ALVES, W. A., OLIVEIRA, E. B., KERKIS, I., DANIEL, M. C., & KARPEL, R. L. (2020) Crotamine Cell-Penetrating Nanocarriers: Cancer-Targeting and Potential Biotechnological and/or Medical Applications. Methods Mol Biol. (Clifton, N.J.) 2118, 61–89. https://doi.org/10.1007/978-1-0716-0319-2_5
LIMA, S. C., PORTA, L. C., LIMA, Á. D. C., CAMPEIRO, J. D., MEURER, Y., TEIXEIRA, N. B., DUARTE, T., OLIVEIRA, E. B., PICOLO, G., GODINHO, R. O., SILVA, R. H., HAYASHI, M. A. F. Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles. PLoS Negl Trop Dis. 12(8):e0006700. 2018. doi: 10.1371/journal.pntd.0006700.
CAMPEIRO, J. D., MARINOVIC, M. P., CARAPETO, F. C., DAL MAS, C., MONTE, G. G., PORTA, L. C., NERING, M. B., OLIVEIRA, E. B., HAYASHI, M. A. F. Oral treatment with a rattlesnake native polypeptide crotamine efficiently inhibits the tumor growth with no potential toxicity for the host animal and with suggestive positive effects on animal metabolic profile. Amino Acids. 50(2):267-278. 2018. doi: 10.1007/s00726-017-2513-3.
HAYASHI, MIRIAN A. F. ; CAMPEIRO, JOANA DARC ; PORTA, LUCAS CARVALHO ; Szychowski, Brian ; Alves, Wendel Andrade ; OLIVEIRA, EDUARDO B. ; Kerkis, Irina ; Daniel, Marie-Christine ; Karpel, Richard L. . Crotamine Cell-Penetrating Nanocarriers: Cancer-Targeting and Potential Biotechnological and/or Medical Applications. Methods in Molecular Biology. 2ed.: Springer US, 2020, p. 61-89.

Caroline Dal Mas

DOUTORADO

Carol

PROJETO:

Atividade das Oligopeptidases Ndel1 e ECA na Esquizofrenia e no Transtorno Bipolar

PUBLICAÇÕES

Nani JV, Dal Mas C, Yonamine CM, Ota VK, Noto C, Belangero SI, Mari JJ, Bressan R, Cordeiro Q, Gadelha A, Hayashi MAF. A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone?. Int J Neuropsychopharmacol. 2020 Jul 22;23(11):721-30. doi: 10.1093/ijnp/pyaa050.
Carvalho MS, Dal Mas C, Nunes DFS, Yonamine CM, Hayashi MAF. METABOLISMO DO TRIPTOFANO EM TRANSTORNOS MENTAIS: UM ENFOQUE NA ESQUIZOFRENIA. Vittalle, v. 29, p. 44-56, 2017. DOI: https://doi.org/10.14295/vittalle.v29i2.6550
Dal Mas C, Carvalho MS, Marins LA, Yonamine CM, Cordeiro Q, McIntyre RS, Mansur RB, Brietzke E, Hayashi MAF. Oligopeptidases activity in bipolar disorder: Ndel1 and angiotensin I converting enzyme. J Affect Disord. 2019 Feb 1;244:67-70. doi: 10.1016/j.jad.2018.10.001.
Nani JV, Yonamine CM, Castro Musial D, Dal Mas C, Mari JJ, Hayashi MAF. ACE activity in blood and brain axis in an animal model for schizophrenia: Effects of dopaminergic manipulation with antipsychotics and psychostimulants. World J Biol Psychiatry. 26:1-11. 2019. doi: 10.1080/15622975.2019.1583372.
Dal Mas C, Nani JV, Noto C, Yonamine CM, da Cunha GR, Mansur RB, Ota VK, Belangero SI, Cordeiro Q, Kapczinski F, Brietzke E, Bressan RA, Gadelha A, Hayashi MAF. Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia. Schizophr Res. 2019 Jun;208:202-208. doi: 10.1016/j.schres.2019.02.021.
Monte GG, Nani JV, de Almeida Campos MR, Dal Mas C, Marins LAN, Martins LG, Tasic L, Mori MA, Hayashi MAF. Impact of nuclear distribution element genes in the typical and atypical antipsychotics effects on nematode Caenorhabditis elegans: Putative animal model for studying the pathways correlated to schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 92:19-30. 2019. doi: 10.1016/j.pnpbp.2018.12.010.
Costa BA, Sanches L, Gomide AB, Bizerra F, Dal Mas C, Oliveira EB, Perez KR, Itri R, Oguiura N, Hayashi MA. Interaction of the rattlesnake toxin crotamine with model membranes. J Phys Chem B. 2014 May 22;118(20):5471-9. doi: 10.1021/jp411886u.
Dal Mas C, Rossato L, Shimizu T, Oliveira EB, da Silva Junior PI, Meis JF, Colombo AL, Hayashi MAF. Effects of the Natural Peptide Crotamine from a South American Rattlesnake on Candida auris, an Emergent Multidrug Antifungal Resistant Human Pathogen. Biomolecules. 2019 May 28;9(6):205. doi: 10.3390/biom9060205.
Campeiro JD, Marinovic MP, Carapeto FC, Dal Mas C, Monte GG, Carvalho Porta L, Nering MB, Oliveira EB, Hayashi MAF. Oral treatment with a rattlesnake native polypeptide crotamine efficiently inhibits the tumor growth with no potential toxicity for the host animal and with suggestive positive effects on animal metabolic profileAmino Acids. 2018 Feb;50(2):267-278. doi: 10.1007/s00726-017-2513-3.
Dal Mas C, Pinheiro DA, Campeiro JD, Mattei B, Oliveira V, Oliveira EB, Miranda A, Perez KR, Hayashi MAF. Biophysical and biological properties of small linear peptides derived from crotamine, a cationic antimicrobial/antitumoral toxin with cell penetrating and cargo delivery abilities. Biochim Biophys Acta Biomembr. 2017 Dec;1859(12):2340-2349. doi: 10.1016/j.bbamem.2017.09.006.
Tasic L, Pontes JGM, Carvalho MS, Cruz G, Dal Mas C, Sethi S, Pedrini M, Rizzo LB, Zeni-Graiff M, Asevedo E, Lacerda ALT, Bressan RA, Poppi RJ, Brietzke E, Hayashi MAF. Metabolomics and lipidomics analyses by ¹H nuclear magnetic resonance of schizophrenia patient serum reveal potential peripheral biomarkers for diagnosis. Schizophr Res. 2017 Jul;185:182-189. doi: 10.1016/j.schres.2016.12.024.
El Chamy Maluf S, Dal Mas C, Oliveira EB, Melo PM, Carmona AK, Gazarini ML, Hayashi MA. Inhibition of malaria parasite Plasmodium falciparum development by crotamine, a cell penetrating peptide from the snake venom. Peptides. 2016 Apr;78:11-6. doi: 10.1016/j.peptides.2016.01.013.
Dal Mas C, Moreira JT, Pinto S, Monte GG, Nering MB, Oliveira EB, Gazarini ML, Mori MA, Hayashi MA. Anthelmintic effects of a cationic toxin from a South American rattlesnake venom. Toxicon. 2016 Jun 15;116:49-55. doi: 10.1016/j.toxicon.2015.11.021.
Marinovic MP, Dal Mas C, Monte GG, Felix D, Campeiro JD, Hayashi MA. Crotamine: Function Diversity and Potential Applications. Snake Venoms. 1ed.: Springer Netherlands, 2016, v. , p. 1-30. DOI: https://doi.org/10.1007/978-94-007-6648-8_28-1

Benjamin Rodríguez Hernandez

MESTRADO

benji circulo

PROJETO: Análise da atividade da prolil-oligopeptidase (POP) em modelo animal para estudo da

esquizofrenia frente ao tratamento com antipsicóticos

CV LATTES

benji circulo

LATTES

Bolsista de Mestrado da CAPES

Possui graduação em CIENCIAS BIOLÓGICAS - Benemérita Universidad Autónoma de Puebla (2015). Clinical laboratory technologist- PEMEX Medical Service at General Hospital, Tula Hidalgo. Practitioner at Biomolecular Detection Center (CDB) - Puebla México participation assisting in the diagnostic at molecular level of respiratory infectious diseases using molecular biology techniques. Also I worked in an study with the research team of the department of Clinical Microbiology of BUAP in the sampling and detection of mycoplasmas in the population of Puebla.

Alunos

Alunos

William Yoshio Oyadomari

PÓS-DOUTORADO