Embedded Files
Acesse o artigo publicado : Strain-Specific Reduction of Ndel1 Enzymatic Activity During Early Zika Virus Infection in the Neonatal Brain
Strain-Specific Reduction of Ndel1 Enzymatic Activity During Early Zika Virus Infection in the Neonatal Brain
Strain-Specific Reduction of Ndel1 Enzymatic Activity During Early Zika Virus Infection in the Neonatal Brain
Our results demonstrate that Ndel1 downregulation is not a conserved feature of flavivirus infection, nor a universal response to ZIKV, but rather a strain-specific signature of ZIKVBR-induced neuropathogenesis. While both ZIKV strains elicited robust inflammatory and interferon responses, only ZIKVBR infection led to a consistent reduction in Ndel1 enzymatic activity, an effect that was independent of route of infection, dissociated from transcriptional regulation, and not recapitulated by DENV or ZIKVAF under identical experimental conditions.
de Farias IS, Oyadomari WY, Parra LR, Ximenes AP, Cordeiro Júnior Q, Fidalgo TM, Hayashi MAF. Increased serum neurodevelopmental biomarker Ndel1 activity in medicated patients with depression is associated with reduced neurite density and neuronal viability independently of intracellular Ndel1 activity. J Affect Disord. 2026 Aug 1;406:121643. doi: 10.1016/j.jad.2026.121643. Epub 2026 Mar 19. PMID: 41864353.
Nani, J. V., J. Y. Hayashi, J. D. Campeiro, et al. 2025. “ Postnatal Mouse Brain Region-Resolved Peptidomic Resource of Conditional Ndel1 Loss: Comparison of Acidic and Alcoholic Extraction Strategies.” Journal of Neurochemistry 169, no. 12: e70330. https://doi.org/10.1111/jnc.70330.
Oyadomari WY, Santiago TC, Basso L, Oliveira V, Cruz FC, Nani JV, Hayashi MAF. Long-term treatment with haloperidol modulates angiotensin I-converting enzyme (ACE) activity in transgenic animal model with construct validity for schizophrenia studies. Brain Res. 2025 Jul 15;1859:149640. doi: 10.1016/j.brainres.2025.149640. Epub 2025 Apr 12. PMID: 40228572.
RNA-seq transcriptome of ZIKV-infected brain organoids reanalysis implicates Ndel1 oligopeptidase and its cytoskeleton protein binding partners in the infection pathogenesis and recovery following interferon treatment
Checa-Robles FJ, Salvetat N, Cayzac C, Menhem M, Favier M, Vetter D, Ouna I, Nani JV, Hayashi MAF, Brietzke E, Weissmann D. RNA Editing Signatures Powered by Artificial Intelligence: A New Frontier in Differentiating Schizophrenia, Bipolar, and Schizoaffective Disorders. Int J Mol Sci. 2024 Dec 3;25(23):12981. doi: 10.3390/ijms252312981. PMID: 39684694; PMCID: PMC11641080.
Pontes JGM, Nani JVS, Correia BSB, Carneiro Costa TBB, Stanisic D, Hayashi MAF, Tasic L. An Investigation of the Sodium Nitroprusside Effects on Serum Lipids in an Animal Model of Schizophrenia by the Magnetic Resonance Study. ACS Omega. 2024 Nov 25;9(49):48480-48487. doi: 10.1021/acsomega.4c07072. PMID: 39676991; PMCID: PMC11635526.
Andreoli L, da Silva Fiorin F, Simplicio H, Hayashi M, Morya E. Developing a Behavioral Box for Assessing Prepulse Inhibition and Neural Activity in Psychiatric Animal Models. J Vis Exp. 2025 Jul 22;(221). doi: 10.3791/67005. PMID: 40788952.
Nani JV, Muotri AR, Hayashi MAF. Peering into the mind: unraveling schizophrenia's secrets using models. Mol Psychiatry. 2025 Feb;30(2):659-678. doi: 10.1038/s41380-024-02728-w. Epub 2024 Sep 8. PMID: 39245692.
Oyadomari WY, Christoff RR, Nani JV, Rabello T, Oliveira V, Higa LM, Garcez PP, Hayashi MAF. Infection by zika virus increase angiotensin I-converting enzyme activity in mouse brain. Biochimie. 2024 Dec;227(Pt A):116-118. doi: 10.1016/j.biochi.2024.07.001. Epub 2024 Jul 2. PMID: 38960371.
Courchesne, E., Taluja, V., Nazari, S., Aamodt, C. M., Pierce, K., Duan, K., Stophaeros, S., Lopez, L., Barnes, C. C., Troxel, J., Campbell, K., Wang, T., Hoekzema, K., Eichler, E. E., Nani, J. V., Pontes, W., Sanchez, S. S., Lombardo, M. V., de Souza, J. S., Hayashi, M. A. F., … Muotri, A. R. (2024). Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms. Molecular autism, 15(1), 22. https://doi.org/10.1186/s13229-024-00602-8
Nani JV, Ushirohira JM, Bradshaw NJ, Machado-de-Sousa JP, Hallak JEC, Hayashi MAF. Sodium nitroprusside as an adjunctive treatment for schizophrenia reduces Ndel1 oligopeptidase activity. Braz J Psychiatry. 2024;46:e20233315. doi: 10.47626/1516-4446-2023-3315. Epub 2023 Nov 23. PMID: 37994832; PMCID: PMC11474453.
Nani JV, Coelho C, Oyadomari WY, Santiago TC, Machado MM, Christoff RR, Garcez PP, Oliveira V, Würtele M, Hayashi MAF. Identification of an ex vivo inhibitor of the schizophrenia biomarker Ndel1 by high throughput screening. Biochem Pharmacol. 2023 Nov;217:115841. doi: 10.1016/j.bcp.2023.115841. Epub 2023 Oct 9. PMID: 37820964.
Publicações dos últimos 5 anos
Publicações dos últimos 5 anos
Oyadomari WY, Anthero GL, Silva MRA, Porta LC, Oliveira V, Reid PF, Sant'Anna OA, Alves WA, Nani JV, Hayashi MAF. Evaluation of tumor growth remission in a murine model for subcutaneous solid tumors - Benefits of associating the antitumor agent crotamine with mesoporous nanosilica particles to achieve improved dosing frequency and efficacy. Int J Pharm. 2023;646:123420. doi: 10.1016/j.ijpharm.2023.123420 .
Hayashi MAF, Salvetat N, Cayzac C, Checa-Robles FJ, Dubuc B, Mereuze S, Nani JV, Molina F, Brietzke E, Weissmann D. Euthymic and depressed bipolar patients are characterized by different RNA editing patterns in blood. Psychiatry Res. 2023;328:115422. doi: 10.1016/j.psychres.2023.115422
Christoff RR, Nani JV, Lessa G, Rabello T, Rossi AD, Krenn V, Higa LM, Tanuri A, Garcez PP, Hayashi MAF. Assessing the role of Ndel1 oligopeptidase activity in congenital Zika syndrome: Potential predictor of congenital syndrome endophenotype and treatment response. J Neurochem. 2023;166(4):763-776. doi: 10.1111/jnc.15918
Campeiro JD, Dam WA, Hayashi MAF, van den Born J. Crotamine/siRNA Nanocomplexes for Functional Downregulation of Syndecan-1 in Renal Proximal Tubular Epithelial Cells. Pharmaceutics 2023;15(6):1576. doi: 10.3390/pharmaceutics15061576
de Paula Faria D, D'Arc Campeiro J, de Souza Junqueira M, Real CC, Marques FLN, Hayashi MAF, Sapienza MT. [18F]FDG and [11C]PK11195 PET imaging in the evaluation of brown adipose tissue - effects of cold and pharmacological stimuli and their association with crotamine intake in a male mouse model. Nucl Med Biol. 2023;122-123:108362. doi: 10.1038/s41598-021-93653-3
Boeynaems S, Ma XR, Yeong V, Ginell GM, Chen JH, Blum JA, Nakayama L, Sanyal A, Briner A, Haver DV, Pauwels J, Ekman A, Schmidt HB, Sundararajan K, Porta L, Lasker K, Larabell C, Hayashi MAF, Kundaje A, Impens F, Obermeyer A, Holehouse AS, Gitler AD. Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease. bioRxiv [Preprint]. 2023:2023.03.09.531820. doi: 10.1101/2023.03.09.531820
Santiago TC, Parra L, Nani JV, Fidalgo TM, Bradshaw NJ, Hayashi MAF. Angiotensin-converting enzymes as druggable features of psychiatric and neurodegenerative disorders. J Neurochem. 2023;166(2):138-155. doi: 10.1111/jnc.15806
Correia BSB, de Moraes Pontes JG, Nani JVS, Villalta F, Mor NC, Bordini D, Brunoni D, Brentani H, Mari JJ, Hayashi MAF, Tasic L. 1H NMR Metabolomics and Lipidomics To Monitor Positive Responses in Children with Autism Spectrum Disorder Following a Guided Parental Intervention: A Pilot Study. ACS Chem Neurosci. 2023;14(6):1137-1145. doi: 10.1016/j.nucmedbio.2023.108362
Marins LAN, Rodríguez B, Nani JV, Oliveira V, Gadelha A, Hayashi MAF. Prolyl oligopeptidase activity (POP) in early stage and medicated schizophrenia and in an animal model for schizophrenia study: In vivo effects of psychopharmacological substances on enzyme activity. Brain Disorders, Volume 10, 2023, 100075, ISSN 2666-4593, doi: 10.1016/j.dscb.2023.100075
Moraes VWR, Santos VM, Suarez ER, Ferraz LS, Lopes RM, Mognol GP, Campeiro JD, Machado-Neto JA, Nascimento FD, Hayashi MAF, Tersariol ILS, Newmeyer DD, Rodrigues T. Targeting Ca2+ and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells. Life (Basel). 2022;12(10):1477. doi: 10.3390/life12101477
Nani JV, Almeida PGC, Hayashi MAF. Neuropeptidases in Psychiatric Disorders. In: Encyclopedia of Behavioral Neuroscience, 2nd edition (Second Edition), Editor(s): Sergio Della Sala, Elsevier, 2022, Pages 283-292, ISBN 9780128216361. doi: 10.1016/B978-0-12-819641-0.00091-8.
Nani JV, Almeida PGC, Noto C, Bressan RA, Brietzke E, Hayashi MAF. Unraveiling the correlation among neurodevelopmental and inflammatory biomarkers in patients with chronic schizophrenia. Nord J Psychiatry. 2022;76(7):559-564. doi: 10.1080/08039488.2021.2023217
El Chamy Maluf S, Hayashi MAF, Campeiro JD, Oliveira EB, Gazarini ML, Carmona AK. South American rattlesnake cationic polypeptide crotamine trafficking dynamic in Plasmodium falciparum-infected erythrocytes: Pharmacological inhibitors, parasite cycle and incubation time influences in uptake. Toxicon 2022;208:47-52. doi: 10.1016/j.toxicon.2022.01.006
Hayashi MAF, Campeiro JD, Yonamine CM. Revisiting the potential of South American rattlesnake Crotalus durissus terrificus toxins as therapeutic, theranostic and/or biotechnological agents. Toxicon. 2022;206:1-13. doi: 10.1016/j.toxicon.2021.12.005
Porta LC, Campeiro JD, Hayashi MAF. A Native CPP from Rattlesnake with Therapeutic and Theranostic Properties. Methods Mol Biol. 2022;2383:91-104. doi: 10.1007/978-1-0716-1752-6_6.
Altaf-Ul-Amin M, Hirose K, Nani JV, Porta LC, Tasic L, Hossain SF, Huang M, Ono N, Hayashi MAF, Kanaya S. A system biology approach based on metabolic biomarkers and protein-protein interactions for identifying pathways underlying schizophrenia and bipolar disorder. Sci Rep. 2021;11(1):14450. doi: 10.1038/s41598-021-93653-3.
Campeiro JD, Nani JV, Monte GG, Almeida PGC, Mori MA, Hayashi MAF. Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for nuclear distribution element genes. Neurochem Int. 2021;147:105047. doi: 10.1016/j.neuint.2021.105047
Correia BSB, Nani JV, Waladares Ricardo R, Stanisic D, Costa TBBC, Hayashi MAF, Tasic L. Effects of Psychostimulants and Antipsychotics on Serum Lipids in an Animal Model for Schizophrenia. Biomedicines. 2021;9(3):235. doi: 10.3390/biomedicines9030235
Trombetta-Lima M, Assis-Ribas T, Cintra RC, Campeiro JD, Guerreiro JR, Winnischofer SMB, Nascimento ICC, Ulrich H, Hayashi MAF, Sogayar MC. Impact of Reck expression and promoter activity in neuronal in vitro differentiation. Mol Biol Rep. 2021;48(2):1985-1994. doi.org/10.1007/s11033-021-06175-6
Nani JV, Lee RS, Yonamine CM, Sant'Anna OA, Juliano MA, Gadelha A, Mari JJ, Hayashi MAF. Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics. Sci Rep. 2020;10(1):18513. doi: 10.1038/s41598-020-75616-2.
Maes M, Nani JV, Noto C, Rizzo L, Hayashi MAF, Brietzke E. Impairments in Peripheral Blood T Effector and T Regulatory Lymphocytes in Bipolar Disorder Are Associated with Staging of Illness and Anti-cytomegalovirus IgG Levels. Mol Neurobiol. 2021;58(1):229-242. doi: 10.1007/s12035-020-02110-1
Demais Publicações
Demais Publicações
Hayashi, M.A.F. et al. (2020). Crotamine Cell-Penetrating Nanocarriers: Cancer-Targeting and Potential Biotechnological and/or Medical Applications. In: Ferrari, E., Soloviev, M. (eds) Nanoparticles in Biology and Medicine. Methods in Molecular Biology, vol 2118. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0319-2
Nani, J.V., Lee, R.S., Yonamine, C.M. et al. Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics. Sci Rep 10, 18513 (2020). https://doi.org/10.1038/s41598-020-75616-2
de Carvalho Porta L, Fadel V, D'Arc Campeiro J, Oliveira EB, Godinho RO, Hayashi MAF. Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine. J Mol Med (Berl). 2020 Nov;98(11):1561-1571. https://doi.org/10.1007/s00109-020-01975-y . Epub 2020 Sep 7. PMID: 32895732.
Nani JV, Dal Mas C, Yonamine CM, Ota VK, Noto C, Belangero SI, Mari JJ, Bressan R, Cordeiro Q, Gadelha A, Hayashi MAF. A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone? Int J Neuropsychopharmacol. 2020 Jul 22;23(11):721–30. https://doi.org/10.1093/ijnp/pyaa050 . Epub ahead of print. Erratum in: Int J Neuropsychopharmacol. 2023 Aug 29;26(8):584. doi: 10.1093/ijnp/pyad038. PMID: 32696960; PMCID: PMC7745254.
Almeida PGC, Nani JV, Oses JP, Brietzke E, Hayashi MAF. Neuroinflammation and glial cell activation in mental disorders. Brain Behav Immun Health. 2019 Dec 27;2:100034. https://doi.org/10.1016/j.bbih.2019.100034 . PMID: 38377429; PMCID: PMC8474594.
Maes M, Nani JV, Noto C, Rizzo L, Hayashi MAF, Brietzke E. Impairments in Peripheral Blood T Effector and T Regulatory Lymphocytes in Bipolar Disorder Are Associated with Staging of Illness and Anti-cytomegalovirus IgG Levels. Mol Neurobiol. 2021 Jan;58(1):229-242. https://doi.org/10.1007/s12035-020-02110-1 . Epub 2020 Sep 11. PMID: 32914395.
Nani JV, Fonseca MC, Engi SA, Perillo MG, Dias CS, Gazarini ML, Korth C, Cruz FC, Hayashi MA. Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity. J Psychopharmacol. 2020 Apr;34(4):467-477. https://doi.org/10.1177/0269881119897562 . Epub 2020 Jan 9. PMID: 31916893.
Nani JV, Yonamine CM, Castro Musial D, Dal Mas C, Mari JJ, Hayashi MAF. ACE activity in blood and brain axis in an animal model for schizophrenia: Effects of dopaminergic manipulation with antipsychotics and psychostimulants. World J Biol Psychiatry. 2020 Jan;21(1):53-63. https://doi.org/10.1080/15622975.2019.1583372 . Epub 2019 Mar 20. PMID: 30806143.
Porta LC, Campeiro JD, Papa GB, Oliveira EB, Godinho RO, Rodrigues T, Hayashi MAF. In vivo effects of the association of the psychoactive phenotiazine thioridazine on antitumor activity and hind limb paralysis induced by the native polypeptide crotamine. Toxicon. 2020 Oct 15;185:64-71. https://doi.org/10.1016/j.toxicon.2020.06.017 . Epub 2020 Jul 2. PMID: 32621838.
Rodríguez B, Nani JV, Almeida PGC, Brietzke E, Lee RS, Hayashi MAF. Neuropeptides and oligopeptidases in schizophrenia. Neurosci Biobehav Rev. 2020 Jan;108:679-693. https://doi.org/10.1016/j.neubiorev.2019.11.024 . Epub 2019 Nov 30. PMID: 31794779.
Bradshaw NJ, Hayashi MA. NDE1 and NDEL1 from genes to (mal)functions: parallel but distinct roles impacting on neurodevelopmental disorders and psychiatric illness. Cell Mol Life Sci. 2017 Apr;74(7):1191-1210. https://doi.org/10.1007/s00018-016-2395-7 . Epub 2016 Oct 14. PMID: 27742926; PMCID: PMC11107680.
Campeiro JD, Dam W, Monte GG, Porta LC, Oliveira LCG, Nering MB, Viana GM, Carapeto FC, Oliveira EB, van den Born J, Hayashi MAF. Long term safety of targeted internalization of cell penetrating peptide crotamine into renal proximal tubular epithelial cells in vivo. Sci Rep. 2019 Mar 1;9(1):3312. https://doi.org/10.1038/s41598-019-39842-7 . PMID: 30824773; PMCID: PMC6397221.
Costa TBBC, Lacerda ALT, Mas CD, Brietzke E, Pontes JGM, Marins LAN, Martins LG, Nunes MV, Pedrini M, Carvalho MSC, Mitrovitch MP, Hayashi MAF, Saldanha NL, Poppi RJ, Tasic L. Insights into the Effects of Crack Abuse on the Human Metabolome Using a NMR Approach. J Proteome Res. 2019 Jan 4;18(1):341-348. https://doi.org/10.1021/acs.jproteome.8b00646 . Epub 2018 Nov 12. PMID: 30387359.
Dal Mas C, Rossato L, Shimizu T, Oliveira EB, da Silva Junior PI, Meis JF, Colombo AL, Hayashi MAF. Effects of the Natural Peptide Crotamine from a South American Rattlesnake on Candida auris, an Emergent Multidrug Antifungal Resistant Human Pathogen. Biomolecules. 2019 May 28;9(6):205. https://doi.org/10.3390/biom9060205 . PMID: 31141959; PMCID: PMC6627186.
Dal Mas C, Carvalho MS, Marins LA, Yonamine CM, Cordeiro Q, McIntyre RS, Mansur RB, Brietzke E, Hayashi MAF. Oligopeptidases activity in bipolar disorder: Ndel1 and angiotensin I converting enzyme. J Affect Disord. 2019 Feb 1;244:67-70. https://10.1016/j.jad.2018.10.001 . Epub 2018 Oct 6. PMID: 30321766.
Dal Mas C, Nani JV, Noto C, Yonamine CM, da Cunha GR, Mansur RB, Ota VK, Belangero SI, Cordeiro Q, Kapczinski F, Brietzke E, Bressan RA, Gadelha A, Hayashi MAF. Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia. Schizophr Res. 2019 Jun;208:202-208. https://doi.org/10.1016/j.schres.2019.02.021 . Epub 2019 Mar 8. PMID: 30857875.
Monte GG, Nani JV, de Almeida Campos MR, Dal Mas C, Marins LAN, Martins LG, Tasic L, Mori MA, Hayashi MAF. Impact of nuclear distribution element genes in the typical and atypical antipsychotics effects on nematode Caenorhabditis elegans: Putative animal model for studying the pathways correlated to schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:19-30. https://doi.org/10.1016/j.pnpbp.2018.12.010 . Epub 2018 Dec 19. PMID: 30578843.
Pedrini M, Cao B, Nani JVS, Cerqueira RO, Mansur RB, Tasic L, Hayashi MAF, McIntyre RS, Brietzke E. Advances and challenges in development of precision psychiatry through clinical metabolomics on mood and psychotic disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13;93:182-188. doi.org/10.1016/j.pnpbp.2019.03.010. Epub 2019 Mar 20. PMID: 30904564.
Tasic L, Larcerda ALT, Pontes JGM, da Costa TBBC, Nani JV, Martins LG, Santos LA, Nunes MFQ, Adelino MPM, Pedrini M, Cordeiro Q, Bachion de Santana F, Poppi RJ, Brietzke E, Hayashi MAF. Peripheral biomarkers allow differential diagnosis between schizophrenia and bipolar disorder. J Psychiatr Res. 2019 Dec;119:67-75.doi.org/10.1016/j.jpsychires.2019.09.009. Epub 2019 Sep 23. PMID: 31568986.
Campeiro JD, Marinovic MP, Carapeto FC, Dal Mas C, Monte GG, Carvalho Porta L, Nering MB, Oliveira EB, Hayashi MAF. Oral treatment with a rattlesnake native polypeptide crotamine efficiently inhibits the tumor growth with no potential toxicity for the host animal and with suggestive positive effects on animal metabolic profile. Amino Acids. 2018 Feb;50(2):267-278.doi.org/10.1007/s00726-017-2513-3 . Epub 2017 Dec 12. PMID: 29235017.
Lima SC, Porta LC, Lima ÁDC, Campeiro JD, Meurer Y, Teixeira NB, Duarte T, Oliveira EB, Picolo G, Godinho RO, Silva RH, Hayashi MAF. Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles. PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006700.doi.org/10.1371/%20journal.pntd.0006700 . PMID: 30080908; PMCID: PMC6095621.
Marinovic MP, Campeiro JD, Lima SC, Rocha AL, Nering MB, Oliveira EB, Mori MA, Hayashi MAF. Crotamine induces browning of adipose tissue and increases energy expenditure in mice. Sci Rep. 2018 Mar 22;8(1):5057. doi.org/10.1038/s41598-018-22988-1 . PMID: 29567992; PMCID: PMC5864908.
e Carvalho, M. da S., Yonamine, C. M., Mas, C. D., Nunes, D. F. S., & Hayashi, M. A. F. (2017). Tryptophan Metabolism in mental disorders: A Focus on Schizophrenia. VITTALLE - Journal of Health Sciences, 29(2), 44–56. https://doi.org/10.14295/vittalle.v29i2.6550
Dal Mas C, Pinheiro DA, Campeiro JD, Mattei B, Oliveira V, Oliveira EB, Miranda A, Perez KR, Hayashi MAF. Biophysical and biological properties of small linear peptides derived from crotamine, a cationic antimicrobial/antitumoral toxin with cell penetrating and cargo delivery abilities. Biochim Biophys Acta Biomembr. 2017 Dec;1859(12):2340-2349. http://dx.doi.org/10.1016/j.bbamem.2017.09.006 . Epub 2017 Sep 6. PMID: 28888370.
Gouvea ES, Ota VK, Noto C, Santoro ML, Spindola LM, Moretti PN, Carvalho CM, Xavier G, Rios AC, Sato JR, Hayashi MA, Brietzke E, Gadelha A, Bressan RA, Cordeiro Q, Belangero SI. Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis. Transl Psychiatry. 2016 Oct 4;6(10):e908.; doi.org/10.1038/tp.2016.159 PMCID: PMC5315542.
Ribeiro HC, Klassen A, Pedrini M, Carvalho MS, Rizzo LB, Noto MN, Zeni-Graiff M, Sethi S, Fonseca FAH, Tasic L, Hayashi MAF, Cordeiro Q, Brietzke E, Sussulini A. A preliminary study of bipolar disorder type I by mass spectrometry-based serum lipidomics. Psychiatry Res. 2017 Dec;258:268-273.dx.doi.org/10.1016/j.psychres.2017.08.039 . Epub 2017 Aug 21. PMID: 28918859.
Rios, A., Maurya, P., Pedrini, M., Zeni-Graiff, M., Asevedo, E., Mansur, R., Wieck, A., Grassi-Oliveira, R., McIntyre, R., Hayashi, M. and Brietzke, E. (2017) Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders. Reviews in the Neurosciences, Vol. 28 (Issue 7), pp. 739-749. https://doi.org/10.1515/revneuro-2017-0001
Sethi S, Pedrini M, Rizzo LB, Zeni-Graiff M, Mas CD, Cassinelli AC, Noto MN, Asevedo E, Cordeiro Q, Pontes JGM, Brasil AJM, Lacerda A, Hayashi MAF, Poppi R, Tasic L, Brietzke E. 1H-NMR, 1H-NMR T2-edited, and 2D-NMR in bipolar disorder metabolic profiling. Int J Bipolar Disord. 2017 Dec;5(1):23. doi.org/10.1186/s40345-017-0088-2 Epub 2017 Jun 4. PMID: 28447334; PMCID: PMC5457743.
Sethi S, Hayashi MA, Sussulini A, Tasic L, Brietzke E. Analytical approaches for lipidomics and its potential applications in neuropsychiatric disorders. World J Biol Psychiatry. 2017 Oct;18(7):506-520. http://dx.doi.org/10.3109/15622975.2015.1117656 . Epub 2016 Jan 26. PMID: 26555297.
Tasic L, Pontes JGM, Carvalho MS, Cruz G, Dal Mas C, Sethi S, Pedrini M, Rizzo LB, Zeni-Graiff M, Asevedo E, Lacerda ALT, Bressan RA, Poppi RJ, Brietzke E, Hayashi MAF. Metabolomics and lipidomics analyses by 1H nuclear magnetic resonance of schizophrenia patient serum reveal potential peripheral biomarkers for diagnosis. Schizophr Res. 2017 Jul;185:182-189. dx.doi.org/10.1016/j.schres.2016.12.024 . Epub 2016 Dec 29. PMID: 28040324.
Dal Mas C, Moreira JT, Pinto S, Monte GG, Nering MB, Oliveira EB, Gazarini ML, Mori MA, Hayashi MA. Anthelmintic effects of a cationic toxin from a South American rattlesnake venom. Toxicon. 2016 Jun 15;116:49-55. dx.doi.org/10.1016/j.toxicon.2015.11.021 . Epub 2015 Dec 20. PMID: 26713409.
El Chamy Maluf S, Dal Mas C, Oliveira EB, Melo PM, Carmona AK, Gazarini ML, Hayashi MA. Inhibition of malaria parasite Plasmodium falciparum development by crotamine, a cell penetrating peptide from the snake venom. Peptides. 2016 Apr;78:11-6. dx.doi.org/doi:10.1016/j.peptides.2016.01.013 . Epub 2016 Jan 21. PMID: 26806200.
Gadelha A, Coleman J, Breen G, Mazzoti DR, Yonamine CM, Pellegrino R, Ota VK, Belangero SI, Glessner J, Sleiman P, Hakonarson H, Hayashi MA, Bressan RA. Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity. Schizophr Res. 2016 Apr;172(1-3):60-7. dx.doi.org/10.1016/j.schres.2016.01.043 . Epub 2016 Feb 2. PMID: 26851141.
Ota VK, Noto C, Santoro ML, Spindola LM, Gouvea ES, Carvalho CM, Santos CM, Xavier G, Higuchi CH, Yonamine C, Moretti PN, Abílio VC, Hayashi MA, Brietzke E, Gadelha A, Cordeiro Q, Bressan RA, Belangero SI. Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis. Eur Neuropsychopharmacol. 2015 Dec;25(12):2416-25. dx.doi.org/10.1016/j.euroneuro.2015.09.013 . Epub 2015 Oct 9. PMID: 26476704.
Page updated
Report abuse